Publications

2017
Interrogating islets in health and disease with single-cell technologies
Carrano, A.C.*, Mulas, F.*, Zeng, C., Sander, M. (2017) Molecular Metabolism, in press. *equal contributors

Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation
Zeng, C.*, Mulas, F.*, Sui, Y., Guan, T., Miller, N., Tan, Y., Liu, F., Jin, W., Carrano, A.C., Huising, M.O., Shirihai, O.S., Yeo, G.W., Sander, M. (2017) Cell Metabolism25:1160-1175 *equal contributors

Ldb1 maintains the terminally differentiated state of pancreatic β-cells
Ediger, B., Hee-Wong, L., Juliana, C., Groff, D., Williams, L., Dominguez, G., Taylor, B.L., Walp, E., Kameswaran, V., Yang, J., Liu, C., Hunter, C., Kaestner, K.H., Najo, A., Li, C., Sander, M., Sussel, L., Won, K.J., May, C., Stoffers, D. (2017) Journal of Clinical Investigation, 127:215-229.

2016

Advances in β-cell replacement and regeneration strategies for treating diabetes
Benthuysen, J.R., Carrano, A.C., Sander, M. (2016) Journal of Clinical Investigation, 126:3651-3660.

Mechanisms of β-cell functional adaptation to changes in workload
Wortham, M., Sander, M. (2016) Diabetes Obes Metab 18 (Suppl. 1), 78-86.

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration
Barrionuevo, F.J., Hurtado A., Kim G-J, Real, F.M., Bakkali, M., Kopp, J.L., Sander, M., Scherer, G., Burgos, M., Jiménez, R. (2016) eLife, 5:e15635.

High-T gives beta cells a boost
Wortham, M., Sander, M. (2016) Cell Metabolism, 23: 761-763.

Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Fox, R.G., Lytle, N.K., Jaquish, V.D., Park, D.F., Ito, T., Bajaj, J., Koechlein, S.C., Zimdahl, B., Yano, M., Kopp, J.L., Kritzik, M., Sicklick, J., Sander, M., Grandgenett, M.P., Hollingsworth, A.M., Shibata, S., Pizzo, D., Valasek, M., Sasik, R., Scadeng, M., Okano, H., Kim, Y., MacLeod, R.A., Lowy, M.A., Reya, T. (2016) Nature, 534:407-11.

Stem cells versus plasticity in liver and pancreas regeneration
Kopp, J.L., Grompe, M., Sander, M. (2016) Nature Cell Biology, 18(3):238-45. doi: 10.1038/ncb3309.

Pancreatic differentiation from human pluripotent stem cells
Vinckier, N., Wang, J., Sander, M. (2016) In Ulrich, H. (ed.): Working with Stem Cells – Quick and easy methodologies and applications. Springer, 257-275.

ECM signaling regulates collective cellular dynamics to control pancreas branching morphogenesis
Shih, H.P., Panlasigui, D., Cirulli, V., Sander, M. (2016) Cell Reports, 14(2):169-79. doi: 10.1016/j.celrep.2015.12.027.

2015

Prdm12 is an evolutionarily conserved determinant of spinal cord V1 interneuron cell fate acting downstream of Pax6 and through cross-repressive interactions with Dbx1 and Nkx6.1
Thelie, A., Desiderio, S., Hanotel, J., Quigley, I., Borromeo, M., Kricha, S., Lahaye, F., Croce, J., Cerda-Moya, G., Ordono-Fernandez, J., Bolle, B., Van Driessche, B., Sander, M., Pierani, A., Van Lint, C., Schubert, M., Lewis, K.J., Johnson, J., Kintner, C., Pieler, T., Henningfeld, K., Bellefroid, E., Van Campenhout, C. (2015) Development, 142:3416-28.

A gene regulatory network cooperatively controlled by Pdx1 and Sox9 governs lineage allocation of foregut progenitor cells
Shih, H.P., Seymour, P.A., Patel, N.A., Xie, R., Wang, A., Liu, P.P., Yeo, G.W., Magnuson, M.A., Sander, M. (2015) Cell Reports, 13: 1-11.

Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M., Ye, L., Kopp, J.L., Sander, M., Carter, H., Deisseroth, K., Verma, I., Karin, M. (2015) Cell, 162, 766–779.

Lineage fate of ductular reactions in liver injury and carcinogenesis
Jörs, S., Jeliazkova, P., Ringelhan, M., Thalhammer, J., Dürl, S., Ferrer, J., Sander, M., Heikenwalder, M., Schmid, R.M., Siveke, J.T., Geisler, F. (2015) J Clin Invest, 125:2445-57.

Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates
Wang, A., Yue, F., Li, Y., Xie, R., Harper, T., Patel, N.A., Muth, K., Palmer, J., Qiu, Y., Wang, J., Lam, D.K., Raum, J.C., Stoffers, D.A., Ren, B., Sander, M. (2015) Cell Stem Cell, 16(4): 386-399. doi:10.1016/j.stem.2015.02.013.

Accompanying Preview: An epigenomic road map for endoderm development Kaestner, K.H. (2015) Cell Stem Cell, 16(4):343-4. doi: 10.1016/j.stem.2015.03.006.

Postnatal beta cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1
Taylor, B.L., Benthuysen, J.R., Sander, M. (2015) Diabetes, 64(3):897-903. doi: 10.2337/db14-0684.

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors
De Vas, M.G., Kopp, J.L., Heliot, C., Sander, M., Cereghini, S., Haumaitre, C. (2015) Development, 142(5):871-82. doi: 10.1242/dev.110759.

A systems view of epigenetic networks regulating pancreas development and beta-cell function
Xie, R., Carrano, A.C., Sander, M. (2015) Wiley Interdiscip Rev Syst Biol Med, 7(1):1-11. doi: 10.1002/wsbm.1287.

2014

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells
Malhotra, G.K., Zhao, X., Edwards, E., Kopp, J.L., Naramura, M., Sander, M., Band, H., Band, V. (2014) BMC Dev Biol, 14(1): 47.

Control of astrocyte progenitor specification, migration and maturation by Nkx6. 1 homeodomain transcription factor
Zhao, X., Chen, Y., Zhu, Q., Huang, H., Teng, P., Zheng, K., Hu, X., Xie, B., Zhang, Z., Sander, M., Qiu, M. (2014) PLoS ONE, 9: e109171.

Ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel™
Shih, H.P., Sander, M. (2014) Methods Mol Biol, 1210:229-237.

Stem cell epigenetics: looking forward
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Limd, D.A., Meshorer, E., Pombo, A., Sander, M., Xu, G.L. (2014) Cell Stem Cell, 14(6):706-9.

Sall1 co-operates with Six2 to actively maintain nephron progenitors in the embryonic kidney
Kanda, S., Ohmori, T., Taguchi, A., Kudo, K., Suzuki, Y., Sato, Y., Hino, S., Sander, M., Sugano, S., Nakao, M., Nishinakamura, R. (2014) J Am Soc Nephrol, ASN. 2013080896.

New insights Into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions?
Kopp, J.L., Sander, M. (2014) Gastroenterology, 146: 24-26.

2013

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
Rockich, B.E., Hrycaj, S.M., Shih, H.P., Nagy, M.S., Ferguson, M.A.H., Kopp, J.L., Sander, M., Wellik, D.M., Spence, J.R. (2013) PNAS, 110(47):E4456-64.

Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells
Taylor, B.L., Liu, F., Sander, M. (2013) Cell Reports, 4(6):1262-75.

Pancreas organogenesis: from lineage determination to morphogenesis
Shih, H.P., Wang, A., Sander, M. (2013) Annu Rev Cell Dev Biol., 29:81-105.

Inactivation of specific beta cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B.L., Harmon, J.S., Sander, M., Robertson, R.P., Powers, A.C., Stein, R. (2013) JCI, 123(8):3305-16.

Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel
Jin, L., Feng, T., Shih, H.P., Zerda, R., Luo, A., Hsu, J., Mahdavi, A., Sander, M., Tirrell, D.A., Riggs, A.D., Ku, H.T. (2013) PNAS, 110(10):3907-12.

Dynamic chromatin remodeling mediated by Polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells
Xie, R., Everett, L.J., Lim, H.W., Patel, N.A., Schug, J., Kroon, E., Kelly, O.G., Wang, A., D’Amour, K.A., Robins, A.J., Won, K.J., Kaestner, K.H., Sander, M. (2013) Cell Stem Cell, 12(2):224-37.

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic beta cell identity
Schaffer, A.E., Taylor, B.L., Benthuysen, J.R., Liu, J., Thorel, F., Yuan, W., Jiao, Y., Kaestner, K.H., Herrera, P.L., Magnuson, M.A., May, C.L., Sander, M. (2013) PLoS Genetics, 9(1):e1003274.

2012

Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
van der Meulen, T., Xie, R., Kelly, O.G., Vale, W.W., Sander, M., Huising, M.O. (2012) PLOS One, 7(12): e52181.

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Kopp, J.L., Figura, G.v., Mayes, E., Liu, F., Dubois, C.L., Morris, J.P., Pan, F.C., Akiyama, H., Wright, C.V.E., Jensen, K., Hebrok, M., Sander, M. (2012) Cancer Cell 22, 1–14.

Accompanying Preview: Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia
Maitra, A., Leach, S.D. (2012) Cancer Cell, 22.

Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
Moran, I., Akerman, I., Bunt, M.v.d, Xie, R., Benazra, M., Nammo, T., Arnes, L., Nakic, N., Garcia-Hurtado, J., Rodriguez-Segui, S., Pasquali, L., Sauty-Colace, C., Beucher, A., Scharfmann, R., Arensbergen, J.v., Johnson, P.R., Berry, A., Lee, C., Harkins, T., Gmyr, V., Pattou, F., Kerr-Conte, J., Piemonti, L., Bemey, T., Hanley, N., Gloyn, A.L., Sussel, L., Langman, L., Brayman, K.L., Sander, M., McCarthy, M.I., Ravassard, P., Ferrer, J. (2012) Cell Metabolism, 16, 435-448.

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
Seymour, P.A., Shih, H.P., Patel, N.A., Freude, K.K., Xie, R., Lim, C.J., Sander, M. (2012) Development, 139, 3363-3372.

Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells
Wang, A., Sander, M. (2012) Journal of Molecular Medicine, 90(7):763-771.

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
Shih, H.P., Kopp, J.L., Sandhu, M., Dubois, C.L., Seymour, P.A., Grapin-Botton, A., Sander, M. (2012) Development, 139, 2488-2499.

2011

Transgenic in vivo overexpression of the transcription factor Nkx6.1 in beta cells does not increase beta cell proliferation, beta cell mass, or improve glucose clearance
Schaffer, A.E., Yang, A.J., Thorel, F., Herrera, P.l., Sander, M. (2011) Molecular Endocrinology, 25:1904-14.

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells
Carpentier, R., Suñer, R.E., Van Hul, N., Kopp, J.L., Beaudry, J.B., Cordi, S., Antoniou, A., Raynaud, P., Lepreux, S., Jacquemin, P., Leclercq, I.A., Sander, M., Lemaigre, F.P. (2011) Gastroenterology, 141(4):1432-8.

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
Dorrell, C., Erker, L., Schug, J., Kopp, J.L., Canaday, P.S., Fox, A.J., Smirnova, O., Duncan, A.W., Finegold, M.J., Sander, M., Kaestner, K.H., Grompe, M. (2011) Genes & Development, 25:1193-203.

Sox9-haploinsufficiency causes glucose intolerance in mice
Dubois, C.L., Shih, H.P., Seymour, P.A., Patel, N.A., Behrmann, J.M., Ngo, V., Sander, M(2011) PLOS One, 6:e23131.

Progenitor cell domains in the developing and adult pancreas
Kopp, J.L., Dubois, C.L., Hao, E., Thorel, F., Herrera, P.L., Sander, M. (2011) Cell Cycle, 10(12):1921-7.

Beginnings of the β-cell: Current perspectives in β-cell development
Seymour, P.A., Sander, M. (2011) Diabetes, 50: 364-376.

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
Kopp, J.L., Dubois, C.L., Schaffer A.E., Hao, E., Shih, H.P., Seymour, P.A., Ma, J., Sander, M. (2011) Development, 138: 653-665.

2010

Ptf1a and Nkx6 transcription factors function as antagonistic lineage determinants in multipotent pancreatic progenitors
Schaffer, A.E., Freude, K.K., Nelson, S.H., Sander, M. (2010) Developmental Cell, 18(6): 1022-9.

2009

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
Wang, S., Jensen, J.N., Seymour, P. A., Hsu, W., Dor, Y., Sander, M., Magnuson, M.A., Serup, P., and Gu, G. (2009) Proc. Natl. Acad. Sci. USA, 106: 9715-9720.

Nkx6.1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse hindbrain
Prakash, N., Puelles, E., Freude, K.K., Trümbach, D., Omodei, D., DiSalvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A., and Wurst, W. (2009) Development, 136: 2545-2555.

2008

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
Seymour, P. A., Freude, K. K., Dubois, C. L., Shih, H. P., Patel, N. A. and Sander, M. (2008) Developmental Biology, 323: 19-30.

Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation
Jonckheere, N., Mayes, E., Shih, H.P., Li, B., Lioubinski, O., Dai, X., Sander, M. (2008) Developmental Biology, 318: 2241-235.

2007

The transcription factors Nkx6.1 and Nkx6.2 have equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
Nelson, S.B., Schaffer, A.E., Sander, M. (2007) Development, 134: 2491-2500.

Sox9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, P.A., Freude, K., Tran, M., Mayes, E., Jensen, J., Kist, R., Scherer, G., Sander, M. (2007) Proc. Natl. Acad. Sci. USA, 104: 1865-1870.

2005

Endodermal expression of Nkx6 genes depends differentially on Pdx1
Pedersen, J.K.*, Nelson, S.B.*, Jørgensen, M.C., Henseleit, K.D., Fujitani, Y. Wright, C.V.E., Sander, M.*, Serup, P.* (2005) Developmental Biology, 288: 487-501.*co-first and co-corresponding authors

Nkx6 transcription factor activity is required for alpha- and beta-cell development in the pancreas
Henseleit, K.D., Nelson, S.B., Kuhlbrodt, K., Hennings, C., Ericson, J., Sander, M. (2005) Development, 132: 3139-3149.

Expression of Nkx6 genes in the hindbrain and gut of the developing mouse
Nelson, S.B., Janiesch, C., Sander, M. (2005) The Journal of Histochemistry and Cytochemistry, 53: 787-790.

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6-regulation and Shh signaling
Cai, J., Qi, Y., Hu, X, Tan, M., Liu, Z., Zhang, J., Li, Q., Sander, M., Qiu, M. (2005) Neuron, 45: 41–53.

2004

Pancreatic islet progenitor cells in Neurogenin 3-YFP knock-add-on mice
Mellitzer, G., Martin, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P.A., Sander, M., Gradwohl, G. (2004) Mol Endocrinol.,18:2765-76.

The MafA transcription factor appears responsible for tissue-specific expression of insulin
Matsuoka, T., Artner, I., Henderson, E., Means, A., Sander, M., Stein, R. (2004) Proc. Natl. Acad. Sci. USA, 101: 2930-2933.

2003

Nkx6.1 controls migration and axon pathfinding of cranial branchiomotor neurons
Müller, M., Jabs, N., Lorke, D., Fritzsch, B., Sander, M. (2003) Development, 130: 5815-5826.

Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor
Liu, R., Cai, J., Hu, X., Tan, M., Qi, Y., German, M.S., Rubenstein, J.R.L., Sander, M., Qiu, M. (2003) Development, 130: 6221-6231.

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motor neuron identity in the hindbrain
Pattyn, A., Vallstedt, A., Dias, J.M., Sander, M., Ericson, J. (2003) Development, 130: 4149-4159.

Expression of Sox transcription factors in the developing mouse pancreas
Lioubinski, O., Müller, M., Wegner, M., Sander, M. (2003) Developmental Dynamics, 227:402–408.

2001

Nkx gene duplication and cross repression: assigning redundant and distinct roles for Nkx6.2 and Nkx6.1 in motor neuron and interneuron specification
Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T., Ericson, J. (2001) Neuron, 13: 743-755.

2000

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Dela Cruz, F., Schwitzgebel, V., Hays-Jordan, A., German, M.S. (2000) Development, 127: 5533-5540.

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
Sander, M., Paydar, S., Ericson J., Briscoe J., Berber E., German M., Jessell, T.M., Rubenstein J.L.R. (2000) Genes & Development, 14, 2134-2139.

1998

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets
Sander, M., Griffen, S.C., Huang, J., German, M.S. (1998) Proc. Natl. Acad. Sci. USA, 95: 11572-11577.

1997

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
Sander, M., Neubüser, A., Kalamaras, J., Ee, H.C., Martin, G.R., German, M.S. (1997) Genes & Development, 11: 1662-1673.

The beta cell transcription factors and development of the pancreas
Sander, M., German, M.S. (1997) Journal of Molecular Medicine, 75: 327-340.

1995

Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27
Djavidani, B., Sander, M., Kreutz, R., Zeh, K., Bader, M., Mellon, S.H., Vecsei, P., Peters, J., Ganten, D. (1995) J. Hyperten., 13: 637-45.

1994

The adrenal P450 system in the hypertensive transgenic rat TGR(mREN2)27 and its regulation by ACTH
Sander, M., Ganten, D., Mellon, S.H. (1994) Proc. Natl. Acad. Sci. USA, 91: 148-152.

1992

Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27
Bader, M., Zhao,Y., Sander, M., Lee, M., Bachmann, J., Boehm, M., Djavidani, B., Peters, J., Mullins, J.J., Ganten, D. (1992) Hypertension, 19: 681-686.

The role of the adrenal gland in the hypertensive transgenic rats TGR(mREN2)27
Sander, M., Bader, M., Djavidani, B., Maser-Gluth, C.,Vecsei, P., Mullins, J.J., Ganten, D. & Peters, J. (1992) Endocrinology, 131: 807-814.