A missense KCNQ1 mutation impairs insulin secretion in neonatal diabetes
Zhou, Z., Gong, M., Pande, A., Lisewski, U., Röpke, T., Purfürst, B., Liang, L., Jia, S., Frühler, S., Marginaunu, A., Zeng, C., Zhu, H., Kühnen, P., Khodaverdi, S., Krill, W., Chen, W., Sander, M.*, Raile, K.*, Izvak, Z.* BioRxiv, https://doi.org/10.1101/2021.08.24.457485
*co-corresponding authors

Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
Heller, S., Li, Z., Lin, Q., Geusz, R., Breunig, M., Hohwieler, M., Zhang, X., Nair G., Seufferlein, T., Hebrok, M, Sander, M., Julier, C., Kleger, A., Costa, I. G., (2021) Communications Biology, 4:1298, https://doi.org/10.1038/s42003-021-02818-3

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
Geusz, R.J., Wang, A., Lam, D.K., Vinckier, N.K., Alysandratos, K.D., Roberts, D.A., Wang, J., Kefalopoulou, S., Qiu, Y., Chiou, J., Gaulton, K.J., Ren, B., Kotton, D.N., Sander, M. (2021) Nature Communications, 12:6636, https://doi.org/10.1038/s41467-021-26950-0

What is a beta cell?
Kaestner, K.H., Campbell-Thompson, M., Dor, Y., Gill, R.G., Glaser, B., Kim, S.K., Sander, M., Stabler, C., Stewart, A.F., Power, A.C. (2021) Molecular Metabolism 53:101323; PMC8452767, https://doi.org/10.1016/j.molmet.2021.101323

Mutations and variants of ONECUT1 in diabetes
Philippi, A., Heller, S., Costa, I.G., Senée, V., Breunig, M., Li, Z., Kwon, G., Russell, R., Illing, A., Lin, Q., Hohwieler, M., Degavre, A, Zalloua, P., Liebau, S., Schuster, M., Krumm, J., Zhang, X., Geusz, R., Benthuysen, J.R., Wang, A., Chiou, J., Gaulton, K.J., Neubauer, H., Simon, E., Klein, T., Wagner, M., Nair, G., Besse, C., Dandine-Roulland, C., Olaso, R., Deleuze, J.F., Kuster, B., Hebrok, M., Seufferlein, T., Sander, M., Boehm, B.O., Oswald, F., Nicolino, M., Julier, C., Kleger, A. (2021) Nature Medicine, 10.1038/s41591-021-01502-7

Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma
Chen, J., Debebe, A., Zeng, N., Kopp, J.L., Sander, M., Stiles, B.L. (2021) Scientific Reports 11:11823; PMC8175600, https://doi.org/10.1038/s41598-021-90958-1

A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus
Wang, G., & Sander, M.  (2021) Nature Reviews Endocrinology, 1-2, https://doi.org/10.1038/s41574-021-00556-4

Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent
Sandoval, D.A., Alonso, L.C., Gannon, M., Sander, M., Sussel, L., Reusch, J.E.B. (2021) Diabetes Care, https://doi.org/10.2337/dci21-0019

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
Chiou, J., Geusz, R.J., Okino, M.L., Han, J.Y., Miller, M., Melton, R., Beebe, E., Benaglio, P., Huang, S., Korgaronka, K, Heller, S., Kleger, A., Preissl, S., Gorkin, D., Sander, M., Gaulton, K.J. (2021) Nature, https://doi.org/10.1038/s41586-021-03552-w

Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation
Wortham, M., Sander, M. (2021) Trends in Endocrinology & Metabolism, https://doi.org/10.1016/j.tem.2021.04.011

Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
Chiou, J., Zeng, C., Cheng, Z., Han, Jee, Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M., Qiu, Y., Sun, Y., Kudtarkar, P., Fang, R., Preissl, S., *Sander, M., *Gorkin, DU., *Gaulton, KJ. (2021) Nature Genetics, https://doi.org/10.1038/s41588-021-00823-0
*co-corresponding authors

Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data
Miko, H., Qiu, Y., Gaertner, B., Sander, M., Ohler, U. (2021) BMC Genomics, https://doi.org/10.1186/s12864-021-07373-z

Systematic analysis of transcription factor binding to noncoding variants in the human genome
Yan, J., Qiu, Y., Ribeiro dos Santos, A., Yin, Y., Li, Y. E., Vinckier, N., Nariai, N., Benaglio, P., Raman, A., Li, X., Fan, S., Chiou, J., Chen, F., Frazer, K. A., Gaulton, K. J., Sander, M., Taipale, J., Ren, B. (2021) Nature, https://doi.org/10.1038/s41586-021-03211-0

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
Geusz, R., Wang, A., Chiou, J., Lancman, J. J., Wetton, N., Kefalopoulou, S., Wang, J., Qiu, Y., Yan, J., Wylward, A., Ren, B., Si Dong, P., *Gaulton, K., *Sander, M. (2021) elife, 10:e59067.
*co-corresponding authors

LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Vinckier, N. K., Patel, N. A., Geusz, R. J., Wang, A., Wang, J., Matta, I., Harrington, A., Wortham, M., Wetton, N., Wang, J., Jhala, U., Rosenfeld, M., Benner, C. W., Shih, H. P., Sander, M. (2020) Nature Communications, 11: 2082. https://doi.org/10.1038/s41467-020-16017-x

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response
Ye, J., Huang, A., Wang, H., Zhang, A. M. Y., Huang, X., Lan, Q., Sato, T., Goyama, S., Kurokawa, M., Deng, C., Sander, M., Schaeffer, D. F., Li, W., Kopp, J. L., Xie, R. (2020). Cell Death & Disease, 11(3): 187. https://doi.org/10.1038/s41419-020-2371-x

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation
Gaertner, B., van Heesch, S., Schneider-Lunitz, V., Felicitas Schulz, J., Witte, F., Blachut, S., Nguyen, S., Wong, R., Matta, Ileana, Hubner, N., Sander, M. (2020) eLife, https://elifesciences.org/articles/58659.

A dual mechanism of enhancer activation by FOXA pioneer factors induces endodermal organ fates
Geusz, R.J., Wang, A., Lam, D.K., Vinckier, N.K., Alysandratos, K.D., Roberts, D.A., Wang, J., Kefalopoulou, S., Qiu, Y., Chiou, J., Gaulton, K.J., Ren, B., Kotton, D.N., Sander, M. (2020) BioRxiv, https://doi.org/10.1101/2020.08.28.263020.

Human stem cell models: lessons for pancreatic development and disease
Gaertner, B., Carrano, A.C., Sander, M. (2019) Genes & Development, 33(21-22): 1475-1490. doi:10.1101/gad.331397.119

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk
Greenwald, W.W., Chiou, J., Yan, J., Qui, Y., Dai, N., Wang, A., Nariai, N., Aylward, A., Han, J.Y., Kadakia, N., Regue, L., Okino, M., Drees, F., Kramer, D., Vinckier, N. Minichiello, L., Gorkin, D., Avruch, J., Frazer, K.A., Sander, M., Ren, B., Gaulton, K.J. (2019) Nature Communications, 10:2078. doi: 10.1038/s41467-019-09975-4

A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells
Jin, W., Mulas, F., Gaertner, B., Sui, Y., Wang, J., Zeng, C., Vinckier, N., Wang, A., Nguyen-Ngoc, K.V., Chiou, J., Kaestner, K.H., Frazer, K., Carrano, A.C., Shih, H.P., Sander, M. (2019) iScience. doi:10.1016/j.isci.2019.10.063

Differential cell susceptibilities to KrasG12D in the setting of obstructive chronic pancreatitis
Shi, C., Pan, F.P., Kim, J.N., Washington, M.K., Padmanabhan, C., Meyer, C.T., Kopp, J.L., Sander, M., Gannon, M., Beauchamp, R.D., Wright, C.V., Means, A.L. (2019). Cellular and Molecular Gastroenterology and Hepatology. doi: 10.1016/j.jcmgh.2019.07.001

In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids
Jun, Y., Lee, J.S., Choi, S., Yang, J.H., Sander, M.*, Chung, S.*, Lee, S.H. (2019) Science Advances, 5(11), eaax4520. https://doi.org/10.1126/sciadv.aax4520, *co-corresponding authors.

Nomenclature for Cellular Plasticity: Are the Terms as Plastic as the Cells Themselves?
Mills, J.C., Stanger, B.Z., Sander M. (2019) Embo J., e103148

Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated histone modifications
Ibarra, A.U., Prause, M., Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen G.L., Billestrup, N. (2019). Molecular and Cellular Endocrinology, 496:110524. doi: 10.1016/j.mce.2019

Nutrient regulation of the islet epigenome controls adaptive insulin secretion
Wortham, M., Liu, F.F., Fleischman, J.Y., Wallace, M., Mulas, F., Vinckier, N.K., Harrington, A.R., Cross, B.R., Chiou, J., Patel, N.A., Sui, Y., Jhala, U.S., Shirihai, O.S., Huising, M.O., Gaulton, K.J., Metallo, C.M., Sander, M. (2019). BioRxiv. doi: 10.1101/742403

Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function
Wortham, M., Benthuysen, J.R., Wallace, M., Savas, J.N., Mulas, F., Divakaruni, A.S., Liu, F., Albert, V., Taylor, B.L., Sui, Y., Saez, E., Murphy, A.N., Yates, J.R. III, Metallo, C.M., Sander, M. (2018) Cell Reports, 25, 2904–2918.

Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogel
Gaetani, R., Aouad, S., Demaddalena, L., Straessle, H., Dzieciatkowska, M., Wortham, M., Bender, H., Nguyen-Ngoc, K., Schmid-Schoenbein, G., George, S., Hughes, C., Sander, M., Hansen, K., Christman, K. (2018). Tissue Engineering, 24, 697-708.

N6-methyladenine DNA modification in glioblastoma 
Xie, Q., Wu, T., Gimple, R., Li, Z., Prager, B., Wu, Q., Yu, Y., Wang, P., Wang, Y., Gorkin, D., Zhang, C., Dowiak, A., Lin, K., Zeng, C., Sui, Y., Kim, L., Miller, T., Jiang, L., Lee, C., Huang, Z., Fang, X., Zhai, K., Mack, S., Sander, M., Bao, S., Kerstetter-Fogle, A., Sloan, A., Xiao, A., Rich, J. (2018) Cell, 175,1-16.

Pancreatic islet-autonomous insulin and smoothened-mediated signaling modulate identity changes of glucagon+ α-cells
Cigliola, V., Ghila, L., Thorel, F., van Gurp, L., Baronnier, D., Oropeza, D., Gupta, S., Miyatsuka, T., Kaneto, H., Magnuson, M.A., Osipovich, A.B., Sander, M., Wright, C.E.V., Thomas, M.K., Furuyama, K., Chera, S., Herrera, P.L. (2018) Nature Cell Biology, 20, 1267-1277.

Epigenetics and Epigenomics: Implications for Diabetes and Obesity
Rosen, E.D., Kaestner, K.H., Natarajan, R., Patti, M.E., Sallari, R., Sander, M., Susztak, K. (2018) Diabetes, 67,1923-1931.

Pancreatic exocrine tissue architecture and integrity are maintained by E-cadherin during postnatal development
Serill, J.D., Sander, M., Shih, H.P. (2018) Scientific Reports, 8:13451.

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis
Das, K.K., Heeg, S., Pitarresi, J.R., Reichert, M., Bakir, B., Takano, S., Kopp, J.L., Wahl-Feuerstein, A., Hicks, P., Sander, M., Rustgi, A.K. (2018) Developmental Dynamics, 247:854-866.

Cell of origin affects tumor development and phenotype in pancreatic ductal adenocarcinoma

Loss of PTEN and activation of Kras synergistically induce formation of intraductal papillary mucinous neoplasia from pancreatic ductal cells in mice
Kopp, J.L., Dubois, C.L., Schaeffer, D.F., Samani, A., Taghizadeh, F., Cowan, R.W., Rhim, A.D., Stiles, B.L., Valasek, M., Sander, M. (2017) Gastroenterology, 154:1509–1523.

LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells
Ediger, B. N., Lim, H. W., Juliana, C., Groff, D. N., Williams, L. T., Dominguez, G., Liu, J.H., Taylor, B.L., Walp, E.R., Kameswaran, V., Yang, J., Liu, C., Hunter, C.S., Kaestner, K.H., Naji, A., Li, C., Sander, M., Stein, R., Sussel, L., Won, K.J., May, C.L., Stoffers, D. A. (2017) The Journal of clinical investigation, 127(1), 215–229. doi:10.1172/JCI88016 

 

 

Advances in β-cell replacement and regeneration strategies for treating diabetes
Benthuysen, J.R., Carrano, A.C., Sander, M. (2016) Journal of Clinical Investigation, 126:3651-3660.

Mechanisms of β-cell functional adaptation to changes in workload
Wortham, M., Sander, M. (2016) Diabetes Obes Metab 18 (Suppl. 1), 78-86.

Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration
Barrionuevo, F.J., Hurtado A., Kim G-J, Real, F.M., Bakkali, M., Kopp, J.L., Sander, M., Scherer, G., Burgos, M., Jiménez, R. (2016) eLife, 5:e15635.

High-T gives beta cells a boost
Wortham, M., Sander, M. (2016) Cell Metabolism, 23: 761-763.

Image based detection and targeting of therapy resistance in pancreatic adenocarcinoma
Fox, R.G., Lytle, N.K., Jaquish, V.D., Park, D.F., Ito, T., Bajaj, J., Koechlein, S.C., Zimdahl, B., Yano, M., Kopp, J.L., Kritzik, M., Sicklick, J., Sander, M., Grandgenett, M.P., Hollingsworth, A.M., Shibata, S., Pizzo, D., Valasek, M., Sasik, R., Scadeng, M., Okano, H., Kim, Y., MacLeod, R.A., Lowy, M.A., Reya, T. (2016) Nature, 534:407-11.

Stem cells versus plasticity in liver and pancreas regeneration
Kopp, J.L., Grompe, M., Sander, M. (2016) Nature Cell Biology, 18(3):238-45. doi: 10.1038/ncb3309.

Pancreatic differentiation from human pluripotent stem cells
Vinckier, N., Wang, J., Sander, M. (2016) In Ulrich, H. (ed.): Working with Stem Cells – Quick and easy methodologies and applications. Springer, 257-275.

ECM signaling regulates collective cellular dynamics to control pancreas branching morphogenesis
Shih, H.P., Panlasigui, D., Cirulli, V., Sander, M. (2016) Cell Reports, 14(2):169-79. doi: 10.1016/j.celrep.2015.12.027.

 

Prdm12 is an evolutionarily conserved determinant of spinal cord V1 interneuron cell fate acting downstream of Pax6 and through cross-repressive interactions with Dbx1 and Nkx6.1
Thelie, A., Desiderio, S., Hanotel, J., Quigley, I., Borromeo, M., Kricha, S., Lahaye, F., Croce, J., Cerda-Moya, G., Ordono-Fernandez, J., Bolle, B., Van Driessche, B., Sander, M., Pierani, A., Van Lint, C., Schubert, M., Lewis, K.J., Johnson, J., Kintner, C., Pieler, T., Henningfeld, K., Bellefroid, E., Van Campenhout, C. (2015) Development, 142:3416-28.

A gene regulatory network cooperatively controlled by Pdx1 and Sox9 governs lineage allocation of foregut progenitor cells
Shih, H.P., Seymour, P.A., Patel, N.A., Xie, R., Wang, A., Liu, P.P., Yeo, G.W., Magnuson, M.A., Sander, M. (2015) Cell Reports, 13: 1-11.

Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer
Font-Burgada, J., Shalapour, S., Ramaswamy, S., Hsueh, B., Rossell, D., Umemura, A., Taniguchi, K., Nakagawa, H., Valasek, M., Ye, L., Kopp, J.L., Sander, M., Carter, H., Deisseroth, K., Verma, I., Karin, M. (2015) Cell, 162, 766–779.

Lineage fate of ductular reactions in liver injury and carcinogenesis
Jörs, S., Jeliazkova, P., Ringelhan, M., Thalhammer, J., Dürl, S., Ferrer, J., Sander, M., Heikenwalder, M., Schmid, R.M., Siveke, J.T., Geisler, F. (2015) J Clin Invest, 125:2445-57.

Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates
Wang, A., Yue, F., Li, Y., Xie, R., Harper, T., Patel, N.A., Muth, K., Palmer, J., Qiu, Y., Wang, J., Lam, D.K., Raum, J.C., Stoffers, D.A., Ren, B., Sander, M. (2015) Cell Stem Cell, 16(4): 386-399. doi:10.1016/j.stem.2015.02.013.

Accompanying Preview: An epigenomic road map for endoderm development Kaestner, K.H. (2015) Cell Stem Cell, 16(4):343-4. doi: 10.1016/j.stem.2015.03.006.

Postnatal beta cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1
Taylor, B.L., Benthuysen, J.R., Sander, M. (2015) Diabetes, 64(3):897-903. doi: 10.2337/db14-0684.

Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors
De Vas, M.G., Kopp, J.L., Heliot, C., Sander, M., Cereghini, S., Haumaitre, C. (2015) Development, 142(5):871-82. doi: 10.1242/dev.110759.

A systems view of epigenetic networks regulating pancreas development and beta-cell function
Xie, R., Carrano, A.C., Sander, M. (2015) Wiley Interdiscip Rev Syst Biol Med, 7(1):1-11. doi: 10.1002/wsbm.1287.

 

 

The role of Sox9 in mouse mammary gland development and maintenance of mammary stem and luminal progenitor cells
Malhotra, G.K., Zhao, X., Edwards, E., Kopp, J.L., Naramura, M., Sander, M., Band, H., Band, V. (2014) BMC Dev Biol, 14(1): 47.

Control of astrocyte progenitor specification, migration and maturation by Nkx6. 1 homeodomain transcription factor
Zhao, X., Chen, Y., Zhu, Q., Huang, H., Teng, P., Zheng, K., Hu, X., Xie, B., Zhang, Z., Sander, M., Qiu, M. (2014) PLoS ONE, 9: e109171.

Ex vivo: culturing embryonic pancreas explants on permeable culture inserts, with fibronectin-coated glass microwells, or embedded in three-dimensional Matrigel™
Shih, H.P., Sander, M. (2014) Methods Mol Biol, 1210:229-237.

Stem cell epigenetics: looking forward
Benitah, S.A., Bracken, A., Dou, Y., Huangfu, D., Ivanova, N., Koseki, H., Laurent, L., Limd, D.A., Meshorer, E., Pombo, A., Sander, M., Xu, G.L. (2014) Cell Stem Cell, 14(6):706-9.

Sall1 co-operates with Six2 to actively maintain nephron progenitors in the embryonic kidney
Kanda, S., Ohmori, T., Taguchi, A., Kudo, K., Suzuki, Y., Sato, Y., Hino, S., Sander, M., Sugano, S., Nakao, M., Nishinakamura, R. (2014) J Am Soc Nephrol, ASN. 2013080896.

New insights Into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions?
Kopp, J.L., Sander, M. (2014) Gastroenterology, 146: 24-26.

 

Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
Rockich, B.E., Hrycaj, S.M., Shih, H.P., Nagy, M.S., Ferguson, M.A.H., Kopp, J.L., Sander, M., Wellik, D.M., Spence, J.R. (2013) PNAS, 110(47):E4456-64.

Nkx6.1 is essential for maintaining the functional state of pancreatic beta cells
Taylor, B.L., Liu, F., Sander, M. (2013) Cell Reports, 4(6):1262-75.

Pancreas organogenesis: from lineage determination to morphogenesis
Shih, H.P., Wang, A., Sander, M. (2013) Annu Rev Cell Dev Biol., 29:81-105.

Inactivation of specific beta cell transcription factors in type 2 diabetes
Guo, S., Dai, C., Guo, M., Taylor, B.L., Harmon, J.S., Sander, M., Robertson, R.P., Powers, A.C., Stein, R. (2013) JCI, 123(8):3305-16.

Colony-forming cells in the adult mouse pancreas are expandable in Matrigel and form endocrine/acinar colonies in laminin hydrogel
Jin, L., Feng, T., Shih, H.P., Zerda, R., Luo, A., Hsu, J., Mahdavi, A., Sander, M., Tirrell, D.A., Riggs, A.D., Ku, H.T. (2013) PNAS, 110(10):3907-12.

Dynamic chromatin remodeling mediated by Polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells
Xie, R., Everett, L.J., Lim, H.W., Patel, N.A., Schug, J., Kroon, E., Kelly, O.G., Wang, A., D’Amour, K.A., Robins, A.J., Won, K.J., Kaestner, K.H., Sander, M. (2013) Cell Stem Cell, 12(2):224-37.

Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic beta cell identity
Schaffer, A.E., Taylor, B.L., Benthuysen, J.R., Liu, J., Thorel, F., Yuan, W., Jiao, Y., Kaestner, K.H., Herrera, P.L., Magnuson, M.A., May, C.L., Sander, M. (2013) PLoS Genetics, 9(1):e1003274.

 

Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells
van der Meulen, T., Xie, R., Kelly, O.G., Vale, W.W., Sander, M., Huising, M.O. (2012) PLOS One, 7(12): e52181.

Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
Kopp, J.L., Figura, G.v., Mayes, E., Liu, F., Dubois, C.L., Morris, J.P., Pan, F.C., Akiyama, H., Wright, C.V.E., Jensen, K., Hebrok, M., Sander, M. (2012) Cancer Cell 22, 1–14.

Accompanying Preview: Disputed paternity: the uncertain ancestry of pancreatic ductal neoplasia
Maitra, A., Leach, S.D. (2012) Cancer Cell, 22.

Human beta cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes
Moran, I., Akerman, I., Bunt, M.v.d, Xie, R., Benazra, M., Nammo, T., Arnes, L., Nakic, N., Garcia-Hurtado, J., Rodriguez-Segui, S., Pasquali, L., Sauty-Colace, C., Beucher, A., Scharfmann, R., Arensbergen, J.v., Johnson, P.R., Berry, A., Lee, C., Harkins, T., Gmyr, V., Pattou, F., Kerr-Conte, J., Piemonti, L., Bemey, T., Hanley, N., Gloyn, A.L., Sussel, L., Langman, L., Brayman, K.L., Sander, M., McCarthy, M.I., Ravassard, P., Ferrer, J. (2012) Cell Metabolism, 16, 435-448.

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
Seymour, P.A., Shih, H.P., Patel, N.A., Freude, K.K., Xie, R., Lim, C.J., Sander, M. (2012) Development, 139, 3363-3372.

Generating cells of the gastrointestinal system: current approaches and applications for the differentiation of human pluripotent stem cells
Wang, A., Sander, M. (2012) Journal of Molecular Medicine, 90(7):763-771.

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
Shih, H.P., Kopp, J.L., Sandhu, M., Dubois, C.L., Seymour, P.A., Grapin-Botton, A., Sander, M. (2012) Development, 139, 2488-2499.

 

Transgenic in vivo overexpression of the transcription factor Nkx6.1 in beta cells does not increase beta cell proliferation, beta cell mass, or improve glucose clearance
Schaffer, A.E., Yang, A.J., Thorel, F., Herrera, P.l., Sander, M. (2011) Molecular Endocrinology, 25:1904-14.

Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes and adult liver progenitor cells
Carpentier, R., Suñer, R.E., Van Hul, N., Kopp, J.L., Beaudry, J.B., Cordi, S., Antoniou, A., Raynaud, P., Lepreux, S., Jacquemin, P., Leclercq, I.A., Sander, M., Lemaigre, F.P. (2011) Gastroenterology, 141(4):1432-8.

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
Dorrell, C., Erker, L., Schug, J., Kopp, J.L., Canaday, P.S., Fox, A.J., Smirnova, O., Duncan, A.W., Finegold, M.J., Sander, M., Kaestner, K.H., Grompe, M. (2011) Genes & Development, 25:1193-203.

Sox9-haploinsufficiency causes glucose intolerance in mice
Dubois, C.L., Shih, H.P., Seymour, P.A., Patel, N.A., Behrmann, J.M., Ngo, V., Sander, M.  (2011) PLOS One, 6:e23131.

Progenitor cell domains in the developing and adult pancreas
Kopp, J.L., Dubois, C.L., Hao, E., Thorel, F., Herrera, P.L., Sander, M. (2011) Cell Cycle, 10(12):1921-7.

Beginnings of the β-cell: Current perspectives in β-cell development
Seymour, P.A., Sander, M. (2011) Diabetes, 50: 364-376.

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
Kopp, J.L., Dubois, C.L., Schaffer A.E., Hao, E., Shih, H.P., Seymour, P.A., Ma, J., Sander, M. (2011) Development, 138: 653-665.

 

Ptf1a and Nkx6 transcription factors function as antagonistic lineage determinants in multipotent pancreatic progenitors
Schaffer, A.E., Freude, K.K., Nelson, S.H., Sander, M. (2010) Developmental Cell, 18(6): 1022-9.

 

Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
Wang, S., Jensen, J.N., Seymour, P. A., Hsu, W., Dor, Y., Sander, M., Magnuson, M.A., Serup, P., and Gu, G. (2009) Proc. Natl. Acad. Sci. USA, 106: 9715-9720.

Nkx6.1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse hindbrain
Prakash, N., Puelles, E., Freude, K.K., Trümbach, D., Omodei, D., DiSalvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A., and Wurst, W. (2009) Development, 136: 2545-2555.

 

A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
Seymour, P. A., Freude, K. K., Dubois, C. L., Shih, H. P., Patel, N. A. and Sander, M. (2008) Developmental Biology, 323: 19-30.

Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation
Jonckheere, N., Mayes, E., Shih, H.P., Li, B., Lioubinski, O., Dai, X., Sander, M. (2008) Developmental Biology, 318: 2241-235.

 

The transcription factors Nkx6.1 and Nkx6.2 have equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
Nelson, S.B., Schaffer, A.E., Sander, M. (2007) Development, 134: 2491-2500.

Sox9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, P.A., Freude, K., Tran, M., Mayes, E., Jensen, J., Kist, R., Scherer, G., Sander, M. (2007) Proc. Natl. Acad. Sci. USA, 104: 1865-1870.

 

Endodermal expression of Nkx6 genes depends differentially on Pdx1
Pedersen, J.K.*, Nelson, S.B.*, Jørgensen, M.C., Henseleit, K.D., Fujitani, Y. Wright, C.V.E., Sander, M.*, Serup, P.* (2005) Developmental Biology, 288: 487-501.*co-first and co-corresponding authors

Nkx6 transcription factor activity is required for alpha- and beta-cell development in the pancreas
Henseleit, K.D., Nelson, S.B., Kuhlbrodt, K., Hennings, C., Ericson, J., Sander, M. (2005) Development, 132: 3139-3149.

Expression of Nkx6 genes in the hindbrain and gut of the developing mouse
Nelson, S.B., Janiesch, C., Sander, M. (2005) The Journal of Histochemistry and Cytochemistry, 53: 787-790.

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6-regulation and Shh signaling
Cai, J., Qi, Y., Hu, X, Tan, M., Liu, Z., Zhang, J., Li, Q., Sander, M., Qiu, M. (2005) Neuron, 45: 41–53.

 

 

Pancreatic islet progenitor cells in Neurogenin 3-YFP knock-add-on mice
Mellitzer, G., Martin, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, P.A., Sander, M., Gradwohl, G. (2004) Mol Endocrinol.,18:2765-76.

The MafA transcription factor appears responsible for tissue-specific expression of insulin
Matsuoka, T., Artner, I., Henderson, E., Means, A., Sander, M., Stein, R. (2004) Proc. Natl. Acad. Sci. USA, 101: 2930-2933.

Nkx6.1 controls migration and axon pathfinding of cranial branchiomotor neurons
Müller, M., Jabs, N., Lorke, D., Fritzsch, B., Sander, M. (2003) Development, 130: 5815-5826.

Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor
Liu, R., Cai, J., Hu, X., Tan, M., Qi, Y., German, M.S., Rubenstein, J.R.L., Sander, M., Qiu, M. (2003) Development, 130: 6221-6231.

Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motor neuron identity in the hindbrain
Pattyn, A., Vallstedt, A., Dias, J.M., Sander, M., Ericson, J. (2003) Development, 130: 4149-4159.

Expression of Sox transcription factors in the developing mouse pancreas
Lioubinski, O., Müller, M., Wegner, M., Sander, M. (2003) Developmental Dynamics, 227:402–408.

Nkx gene duplication and cross repression: assigning redundant and distinct roles for Nkx6.2 and Nkx6.1 in motor neuron and interneuron specification
Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T., Ericson, J. (2001) Neuron, 13: 743-755.

Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
Sander, M., Sussel, L., Conners, J., Scheel, D., Kalamaras, J., Dela Cruz, F., Schwitzgebel, V., Hays-Jordan, A., German, M.S. (2000) Development, 127: 5533-5540.

Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates
Sander, M., Paydar, S., Ericson J., Briscoe J., Berber E., German M., Jessell, T.M., Rubenstein J.L.R. (2000) Genes & Development, 14, 2134-2139.

A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets
Sander, M., Griffen, S.C., Huang, J., German, M.S. (1998) Proc. Natl. Acad. Sci. USA, 95: 11572-11577.

Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
Sander, M., Neubüser, A., Kalamaras, J., Ee, H.C., Martin, G.R., German, M.S. (1997) Genes & Development, 11: 1662-1673.

The beta cell transcription factors and development of the pancreas
Sander, M., German, M.S. (1997) Journal of Molecular Medicine, 75: 327-340.

Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27
Djavidani, B., Sander, M., Kreutz, R., Zeh, K., Bader, M., Mellon, S.H., Vecsei, P., Peters, J., Ganten, D. (1995) J. Hyperten., 13: 637-45.

The adrenal P450 system in the hypertensive transgenic rat TGR(mREN2)27 and its regulation by ACTH
Sander, M., Ganten, D., Mellon, S.H. (1994) Proc. Natl. Acad. Sci. USA, 91: 148-152.

Role of tissue renin in the pathophysiology of hypertension in TGR(mREN2)27
Bader, M., Zhao,Y., Sander, M., Lee, M., Bachmann, J., Boehm, M., Djavidani, B., Peters, J., Mullins, J.J., Ganten, D. (1992) Hypertension, 19: 681-686.

The role of the adrenal gland in the hypertensive transgenic rats TGR(mREN2)27
Sander, M., Bader, M., Djavidani, B., Maser-Gluth, C.,Vecsei, P., Mullins, J.J., Ganten, D. & Peters, J. (1992) Endocrinology, 131: 807-814.