Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

CIRM intern Michael Schlichting joins the Sander lab

The Sander lab publishes paper in Cell Metabolism: "Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal Beta Cell Proliferation"

Zeng and Mulas et al., 2017, Cell Metabolism 25, 1160–1175

Dr. Kim-Vy Nguyen-Ngoc is awarded a JDRF postdoctoral fellowship

Doctoral student Ryan Geusz joins the Sander lab

@msanderlab

- December 1, 2017

RT @MDC_Berlin: Many thanks to Maike Sander who shared lots of exciting and yet unpublished results! #mdc25 https://t.co/krX4QEpxM3
h J R
@msanderlab

- December 1, 2017

RT @MDC_Berlin: Maike Sander, Director of the Pediatric Diabetes Research Center at @UCSanDiego now is speaking about #diabetes, disease me…
h J R
@msanderlab

- November 15, 2017

Happy hour with our now former project scientist Allen Wang. Best of luck Allen in your new job! https://t.co/EgC2jigmzo
h J R
@msanderlab

- November 15, 2017

RT @HIRN_CC: @msanderlab Thank you @msanderlab for all the great advancements coming from your grant. We are excited about your accomplishm…
h J R
@msanderlab

- November 14, 2017

Thank you #HIRN for all your support. Happy World Diabetes Day! https://t.co/iLqubQDVeT
h J R