Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- October 19, 2021

Very nice review on beta-cell heterogeneity from @BennyScience and @KravetsVira. It nicely summarizes what we do and don't understand about functional heterogeneity and molecular underpinnings. https://t.co/m2L2HOiqjT
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@msanderlab

- October 18, 2021

ONECUT/HNF6 mutations cause early onset diabetes. From human genetics to mechanistic studies in hPSC models of beta cell development. Congrats to Alex Kleger! It was a delight to contribute to this work and see our gene regulatory maps put to use. https://t.co/JCIkdJHSZD
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@msanderlab

- October 14, 2021

@HIRN_CC: HIRN Webinar: "Elucidating the Endocrine-Exocrine Communication Axis in the Pancreas: Implications for Disease" #Diabetes #Pancreas #PancreaticCancer #CFRD #Pancreatitis Date: Thurs Oct 21 Time: 11:00 AM PDT | 2:00 PM EDT Duration: 1.5 hours Register https://t.co/yxrySLS90k
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@msanderlab

- October 13, 2021

@WRISGMeeting: There’s still time to register for WRISG 2021. We have ~80 registered attendees and 48 fantastic trainee talks lined up. More to come soon. Reduced registration and hotel room rate is in place until Friday October 15th. Register here: https://t.co/phPxueYfEr
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