Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

CIRM intern Michael Schlichting joins the Sander lab

The Sander lab publishes paper in Cell Metabolism: "Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal Beta Cell Proliferation"

Zeng and Mulas et al., 2017, Cell Metabolism 25, 1160–1175

Dr. Kim-Vy Nguyen-Ngoc is awarded a JDRF postdoctoral fellowship

Doctoral student Ryan Geusz joins the Sander lab

@msanderlab

- October 11, 2017

RT @CIRMnews: From our CIRM family to yours: Happy #StemCellAwarenessDay! #stemcells https://t.co/kl9p5bOUKA
h J R
@msanderlab

- October 4, 2017

RT @NatureRevEndo: https://t.co/uOGFxcaplB Insights into beta cell regeneration for #diabetes via integration of molecular landscapes in hu…
h J R
@msanderlab

- September 28, 2017

Exciting work from our UCSD colleagues: Exosomes are the Missing Link to Insulin Resistance: https://t.co/NV6vrKutvh
h J R
@msanderlab

- September 19, 2017

RT @HIRN_CC: Wishing all our Postdocs a wonderful week. You are the future of #T1D scientific research! #HIRN #HIRNPostdocs #NPAW2017 @nati…
h J R
@msanderlab

- August 30, 2017

Check out this new method for isolating beta cell progenitors from hESC cultures: https://t.co/7E3XCKJMi6
h J R