Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

Postdoctoral Fellow Han Zhu joins the Sander lab

Dr. Maike Sander receives the Humboldt Research Award

CIRM intern Michael Schlichting joins the Sander lab

The Sander lab publishes paper in Cell Metabolism: "Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal Beta Cell Proliferation"

 

Zeng and Mulas et al., 2017, Cell Metabolism 25, 1160–1175

@msanderlab

- March 28, 2018

Maike receives Humboldt Research Award in Bamberg Germany. https://t.co/lRdN85zh9h
h J R
@msanderlab

- March 21, 2018

RT @DRG_Kings: Excellent talk by Prof Maike Sander at @DRG_Kings on the molecular regulation of pancreatic beta cell mass and function. htt…
h J R
@msanderlab

- March 13, 2018

RT @berlinnovation: Looking forward to meet Maike Sander @UCSanDiego at our Symposium. She will talk about #diabetes, disease mechanisms a…
h J R
@msanderlab

- December 29, 2017

Saying goodbye to our postdoc Dennis. Wishing you the best in your future endeavors! https://t.co/jSgedkBk3u
h J R
@msanderlab

- December 18, 2017

Enjoying some Feuerzangenbowle and a white elephant gift exchange at Maike's house. Happy holidays! https://t.co/MIWB3f05Hk
h J R