Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

Postdoctoral Fellow Han Zhu joins the Sander lab

Dr. Maike Sander receives the Humboldt Research Award

CIRM intern Michael Schlichting joins the Sander lab

The Sander lab publishes paper in Cell Metabolism: "Pseudotemporal Ordering of Single Cells Reveals Metabolic Control of Postnatal Beta Cell Proliferation"

 

Zeng and Mulas et al., 2017, Cell Metabolism 25, 1160–1175

@msanderlab

- May 14, 2018

RT @HIRN_CC: The HIRN Year 3 Executive Summary Report has been published. We welcome you to download a copy and learn more about the goals,…
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@msanderlab

- May 11, 2018

Our awesome postdocs Kim-Vy and Matt presenting their exciting research at the #HIRN2018 Annual Investigator Meetin… https://t.co/yUc47waCdK
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@msanderlab

- April 25, 2018

RT @manoliskellis: Type 2 Diabetes Genomics #T2G18 meeting on functional dissection of the diabetic genome. Group shot at @NIDDKgov @NIH. T…
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@msanderlab

- April 24, 2018

RT @DanielJDrucker: @annagloyn @msanderlab @kjgaulton Of course, in 5 weeks you can catch @annagloyn and @msanderlab & other great speakers…
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