Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- March 15, 2019

Two exciting papers with perspective in Science report role for class of histone demethylases in oxygen sensing ind… https://t.co/Uge9Jw60HK
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@msanderlab

- March 14, 2019

RT @LickertHeiko: Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets: Cell Metabolism https…
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@msanderlab

- March 12, 2019

Diabetes has long been known to be associated with pancreatic cancer. This study now shows a link between glucose l… https://t.co/cdPbb7fd4t
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@msanderlab

- March 12, 2019

It has been a privilege to be a mentor @Cirm Bridges to Stem Cells. So many successful students have graduated from… https://t.co/ebfa5teOdK
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@msanderlab

- March 11, 2019

Saying goodbye to Nikki and Susan at The Bella Vista Caffe. Best luck of luck in your new jobs! https://t.co/ORQb5KPMA7
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