Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- July 19, 2021

Congratulations to Matt and Bastian! Matt received UCSD/UCLA Diabetes Research Center Pilot & Feasibility Grant to launch his independent research and Bastian Larry L. #Hillblom Foundation Postdoctoral Fellowship. Stay tuned for interesting islet physiology to come. https://t.co/iuIUSMrFGQ
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@msanderlab

- July 6, 2021

Looking forward to presenting at Indiana Biosciences tomorrow - bright and early at 7:30 am PDT. https://t.co/vdB9MdZ2rW
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@msanderlab

- June 25, 2021

Our @UCSDBMS student Ryan Geusz presenting his studies on directed pioneering #ISSCR2021. He found that changing the binding affinity for a pioneer TF in a single enhancer is sufficient to alter target gene activation thresholds and cell lineage allocation. https://t.co/R1Hig5mRjs
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