Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- January 14, 2021

Interesting work by Li group showing a role for a metabolically regulated histone modification in endoderm developm… https://t.co/rj4pHlz4Xn
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@msanderlab

- January 12, 2021

RT @npburtt: Tackling #type1diabetes: @T2DKP expands to address the genetics & functional studies of T1D as part of #CommonMetabolicDisease…
h J R
@msanderlab

- January 8, 2021

RT @Cherie_Stabler: We are hiring! Seeking a new postdoctoral associate for JDRF/NIH funded projects on cell-based treatments for type 1 di…
h J R
@msanderlab

- December 23, 2020

Our postdoc Vy surprised us with this Sander lab holiday mug! We all need a little cheer after a challenging 2020.… https://t.co/OItMWF4gPr
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