Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- April 17, 2019

RT @MaehrLab: Studying molecular basis of human stem cell differentiation and endoderm development through combined CRISPR perturbations an…
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@msanderlab

- April 5, 2019

A helpful and compelling guide for how to make scientific meetings more diverse and inclusive. Important to know yo… https://t.co/EJkhMP3pEv
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@msanderlab

- April 3, 2019

Big shout-out to @annagloyn for an abolutely fantastic #IsletsInOx2019. Superb science, diverse speakers- many youn… https://t.co/YlfMnbLn9h
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@msanderlab

- April 2, 2019

RT @ATJCagan: Maike Sander on epigenetic mechanisms regulating the beta cell response to feeding/fasting #ISLETSINOX2019 https://t.co/25mwK
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