Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.
To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.
Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.
We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.
Dr. Maike Sander receives the Humboldt Research Award
@msanderlab Retweeting our call for senior scientist or postdoc at the Max Delbrueck Center in Berlin with correct link to application website. 1. iPSC-islet organoids 2. Metabolomics 3. Single-cell biology and screens https://t.co/jubYzGifhb
@msanderlab @MDC_Berlin: Join @msanderlab as a #postdoc! It aims to understand & reverse pancreatic beta cell dysfunction in #diabetes. It employs #hPSC-based models and interrogates these models combining functional & #singlecell based genomic assays. #postdocjobs 👉https://t.co/LY6GKEGnn8 https://t.co/psdmzsujks
@msanderlab Join our team @MDC_Berlin as senior scientist or postdoc! 1. iPSC-islet organoids 2. Metabolomics 3. Single-cell biology and screens https://t.co/L8cNyst8dN
@msanderlab @mvisbeck: Helmholtz delegation visit to Sydney. Wonderful discussions with a perfect view of Sydney harbor. @KatrinJM @msanderlab https://t.co/SAmLxabZaW
@msanderlab Sites of LSD1 recruitment in human islets are enriched for T2D-associated variants, revealing a potential mechanism whereby genetic background influences adaptive insulin secretion. Stay tuned to @WorthamLab who will continue this exciting research. Much more to come! 3/3