Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

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@msanderlab

- November 7, 2019

Thank you Wash U for inviting me for DRC Diabetes Day. Great to catch up with colleagues ⁦@JeffreyRMillman⁩ ⁦… https://t.co/Qp0tlBTbJE
h J R
@msanderlab

- November 2, 2019

Out today! Awesome piece of work by our postdoc Bjoern Gaertner who comprehensively reviewed what human pluripotent… https://t.co/Gw8mnKWVar
h J R
@msanderlab

- October 29, 2019

Very much look forward to this conference. Progress in instructing stem cells would not be possible without profoun… https://t.co/drUjGdx7j5
h J R