Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

Postdoctoral Fellow Han Zhu joins the Sander lab

Dr. Maike Sander receives the Humboldt Research Award

CIRM intern Michael Schlichting joins the Sander lab

Congratulations to Wen and Nick on their new jobs!

@msanderlab

- July 17, 2018

Important paper and conversation about pseudo islet approach. Methodology has applications also for iPSC-derived is… https://t.co/wZaMkJ0Izy
h J R
@msanderlab

- July 1, 2018

Deletion of a single enhancer has a surprisingly large biological effect: https://t.co/rL26uaNXVd
h J R
@msanderlab

- June 19, 2018

RT @UCSDBMS: Chris Glass and Bing Ren investigate effects of genetic variation on #transcription factor binding and function in #macrophage…
h J R
@msanderlab

- June 18, 2018

Interesting paper from the Glass lab. https://t.co/NIzvqtBilG
h J R
@msanderlab

- June 6, 2018

Celebrating with Nick at Ballast Point Brewery. Good luck Nick with your new job at Illumina! https://t.co/eoqADWB4gw
h J R