Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

 

APPLY HERE

 

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- September 22, 2018

RT @KSusztak: Our 2017 meeting summary on Epigenetics and Diabetes it out https://t.co/iVfpgApbiS Rosen, Patti @MelinaClaussnit @BIDMChealt…
h J R
@msanderlab

- September 21, 2018

Our former postdoc Ben Shih is recruiting for his lab at @cityofhope! https://t.co/ROoYE5xsPK https://t.co/7rPoTDAH33
h J R
@msanderlab

- September 10, 2018

Check out new work from the Shih lab showing how cadherin-mediated cell-cell adhesion affects #pancreas organ homeo… https://t.co/m2AWPm82No
h J R
@msanderlab

- September 5, 2018

RT @ISLETSINOX2019: REGISTRATION IS NOW OPEN FOR THE 3RD JOINT MEETING OF THE EASD ISLET STUDY GROUP & BETA-CELL WORKSHOP (April 1-3rd 2019…
h J R
@msanderlab

- August 31, 2018

Interesting new work from our Salk colleague Satchin Panda and postdoc Amandine Chaix on beneficial metabolic effec… https://t.co/b2uctUjwpY
h J R