Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- May 23, 2022

@HIRN_CC: Upcoming Meeting: Engineering Multicellular Tissues hosted by the EU H2020 FET-Open Pan3DP Consortium @Pan3DP (a consortium with the goal of developing an innovative bioprinting approach for generating pancreatic tissue). *June 19-20 in London; Virtual Participation is FREE! https://t.co/RD6QlBxaoj
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@msanderlab

- May 21, 2022

@KravetsVira: Just signed my letter of intent! As of November 2022 I'll be joining @UCSDbe and @UCSD department of Pediatrics and starting my own lab! Excited to work with @msanderlab, @kjgaulton and many more outstanding scientists. https://t.co/B1rYAIjVc8
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@msanderlab

- May 21, 2022

@SoleimanpourLab @KravetsVira @UCSDbe @UCSD @kjgaulton We are excited to welcome you as a colleague at @UCSDbe @UCSDHealthSci. Incoming @UCSDBMS students 📣check out @KravetsVira‘s work: optical imaging, computation, #diabetes. Great opportunity!!!
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@msanderlab

- May 18, 2022

@DiabetologiaJnl: What makes a beta cell ‘grow up’? @BioBarsby and @OtonkoskiT review recent findings on the synergistic metabolic, transcriptomic and circadian regulation of beta cell maturation #betacell #islets #diabetes https://t.co/diQi0Xt3ks 🔓 #toptweettuesday https://t.co/3AGeHMdoB6
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@msanderlab

- May 16, 2022

Looking forward to participating in @JDRF @NIDDKgov workshop on cell therapy for #T1D. May 18/19. Important and timely questions to discuss: What is optimal cell source & transplantation site? Can we CRIRSP hypoimmunogenic cells? How do we scale? https://t.co/5Pm7f6EJUs
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