Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- November 10, 2018

Check out these two back-to-back papers on ER stress and beta-cell proliferation from @OtonkoskiL and Gil Leibowitz… https://t.co/dybvkEY5eE
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@msanderlab

- November 2, 2018

Important conversation about how to assess function of hiPSC/hESC-derved beta cells. https://t.co/DhmClQXyn9
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@msanderlab

- October 26, 2018

RT @UCSDMedSchool: A $3.3M @NIDDKgov will allow researchers, led by Maike Sander, Bing Ren, @kjgaulton, to map the pancreatic islets to dev…
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@msanderlab

- October 24, 2018

Preprints of our study on #proteome dynamics in the maturing #islets are out. Led by our awesome postdoc Matt Worth… https://t.co/LFJowFHTCk
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@msanderlab

- October 24, 2018

Nice news coverage about our new collaborative award @HIRN_CC with resources from @DiabetesnPOD. We look forward to… https://t.co/qy1eowclRl
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