Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- September 28, 2022

@CKarampelias Thanks! Yes, this is what the data suggest.
h J R
@msanderlab

- September 27, 2022

Enterochromaffin-like cells in stem cell islets (SC-ECs) resemble fetal β-cells and are not pancreas-aberrant CDX2 regulates SC-EC identity Identified signal-dependent gene regulatory programs insufficiently activate in SC-β-cells Sex hormones promote β-cell proliferation
h J R
@msanderlab

- September 27, 2022

Happy to share our new study characterizing gene regulatory programs of stem cell islet cell types by single-nucleus ATAC/RNA-seq. Highlights in thread. Thanks, @LabSpagnoli @kjgaulton @powersac_TN for your contributions. https://t.co/vEE0v3xvPK
h J R
@msanderlab

- September 27, 2022

Now out in Diabetes. We found systemic administration of LSD1 inhibitors prevents/reverses #diabetes, #obsity, and #NAFLD in mouse models. For clues on the mechanism check out the paper. Thank you @Philip_Gordts for a great collaboration. https://t.co/ErIY2DzJ9A
h J R