Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- August 14, 2018

Postdoctoral Researcher in Single Cell Epigenomics and Genetics at UC San Diego : San Diego, CA, United States : Na… https://t.co/ozxqVuWtM4
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@msanderlab

- August 13, 2018

We are looking for a #postdoc researcher for integrative analysis of #SingleCell data as part of a NIH-funded multi… https://t.co/kai0d2bS50
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@msanderlab

- August 13, 2018

The Scientist nicely summarizes evidence around irreproducibility of recent Cell papers claiming beta cell regenera… https://t.co/nR5VkDVQ34
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@msanderlab

- August 9, 2018

New mechanistic link between diet-induced obesity and metabolic gene transcription in the liver: https://t.co/Ht4REiH8cf
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@msanderlab

- August 9, 2018

The ever-growing single cell toolbox now enables faithful cell lineage reconstruction from steady-state scRNA-seq d… https://t.co/LlAxauMs8D
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