Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- December 7, 2018

Sander lab team @HIRN_CC discussing engineering approaches for human islet organoid models. https://t.co/MIKeADJv1d
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@msanderlab

- December 5, 2018

Together, our findings build a model wherein #metabolic rewiring associated with increased abundance of mitochondri… https://t.co/dDvCliH4WL
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@msanderlab

- December 5, 2018

We assessed production of several mitochondrial metabolites, revealing an age-related increase in malate levels dur… https://t.co/Vpw1mtRy5H
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@msanderlab

- December 5, 2018

#Mitochondria can produce signals that activate the amplifying pathway. Considering that mitochondrial #metabolic p… https://t.co/kaAMkjfUIF
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@msanderlab

- December 5, 2018

Adult #islets secrete more #insulin in response to #glucose under both normal conditions and when #betacells are de… https://t.co/JQ9a71RqGY
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