Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- May 15, 2019

Only 4 days left to register and submit your abstract for the 2019 Gordon Research Conference on Pancreatic Disease… https://t.co/sx4ycXTv9e
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@msanderlab

- May 7, 2019

Great collaborative work of @UCSDHealth AMP T2D-GENES project, including @kjgaulton, Bing Ren, @KellyFrazer3,… https://t.co/EZM2GWUSm9
h J R
@msanderlab

- May 7, 2019

RT @DanielJDrucker: Initiating β-cell proliferation, alone, before #islet infiltration by immune cells alters the identity of mouse β cells…
h J R
@msanderlab

- May 2, 2019

Saying goodbye to our dearest Nancy. It has been an absolute pleasure working with you. We will miss your bright sm… https://t.co/uPlIZco86q
h J R
@msanderlab

- May 2, 2019

Only 2 weeks left to submit your abstract for the 2019 Gordon Research Conference on Pancreatic Diseases. Slots are… https://t.co/UOYBn967KJ
h J R