Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Congratulations to Wen and Nick on their new jobs!

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- January 20, 2019

Important conversation by @AlquierThierry about need to consider circadian rhythm when studying effects of fasting/… https://t.co/rmBfyvPofv
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@msanderlab

- January 17, 2019

Another single cell RNA-seq study of developing pancreas! This study from Melton lab provides new insights into isl… https://t.co/joVUr9Uupw
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@msanderlab

- January 17, 2019

New protocol for generating beta cells from human ESC/iPSC by @JeffreyRMillman! https://t.co/Y41sCp5ju8
h J R
@msanderlab

- January 8, 2019

Study from Gu lab provides new insight into endocrine lineage bias of pancreatic progenitors and suggests role for… https://t.co/GGHraEyFUA
h J R
@msanderlab

- January 4, 2019

New insights into the role of islet macrophages in regulation of insulin secretion and beta cell proliferation in d… https://t.co/iKDXQvNlbk
h J R