Research in the Sander group is focused on understanding the molecular mechanisms that underlie the formation and function of insulin-producing beta cells in the pancreas, which are affected in diabetes. Our laboratory aims to identify strategies for beta cell regeneration and replacement in order to develop novel treatments for diabetes.

To understand cellular processes leading to diabetes, we employ genetic human pluripotent stem cell (hPSC)-based and mouse models. We interrogate these models with massively parallel sequencing and bioinformatic approaches and use functional assays to link molecular phenotypes to cell function and whole body physiology.

Our research is multi-disciplinary and highly collaborative. As part of the NIH-funded Human Islet Research Network (HIRN) we are generating a 3D islet organoid on a Chip and as part of the NIH-funded T2D-GENES Consortium we are using hPSC models to establish how genetic risk for diabetes causes cellular phenotypes.

We are looking for a postdoctoral researcher/senior scientist for integrative analysis of single cell data.

Dr. Maike Sander receives the Humboldt Research Award

@msanderlab

- December 1, 2022

Congratulations πŸ‘πŸ»πŸ‘πŸ»to Han for a well-deserved award. Here, you can read more about his recent work: https://t.co/vEE0v3y3Fi https://t.co/NIE8RbcmSj
h J R
@msanderlab

- November 12, 2022

Another great collaboration with @kjgaulton. Integration of findings from islet single-cell genomics, CRISPR LOF screen in b-ENDO cells, SELEX-seq, and genetic association studies. https://t.co/BzOdd8NyLQ
h J R
@msanderlab

- November 2, 2022

@CUDiabetes: WE ARE HIRING! The Barbara Davis Center for Diabetes is looking for an Assistant/Associate Professor (Tenure Track). Please share within your networks! https://t.co/g7qhUkPtMk
h J R
@msanderlab

- October 31, 2022

We show that vasculature-derived BMP4 increases and synchronizes glucose-induced Ca2+ responses of stem cell beta cells. 4/4 https://t.co/lGhbAiACRg
h J R