Kim-Vy Nguyen-Ngoc, Ph.D.
JDRF Research Fellow
My previous training includes a B.Sc. in Biotechnology from University of Sciences, Ho Chi Minh city, Vietnam, and a M.Sc. in biomedical sciences from Radboud University Nijmegen in the Netherlands. I conducted my Ph.D. training with Dr. Andrew Ewald at the Department of Cell Biology, Johns Hopkins University, where I developed three-dimensional (3D) organotypic culture models to investigate novel mechanisms governing tumor invasion, mammary branching morphogenesis, and epithelial cell proliferation. I joined the Sander lab in April 2015 with the aim to develop a sustainable culture model of human embryonic stem cell-derived beta cells, which will serve as a platform for diabetes disease modeling and drug testing. I have incorporated recent advanced technologies including three-dimensional 3D organotypic culture, beta cell differentiation methods, in vitro vascularization, and microfluidic devices.
Gaetani R, Aouad S, Demaddalena L, Straessle H, Dzieciatkowska M, Wortham M, Bender H, Nguyen-Ngoc K-V, Schmid-Schoenbein G, George S, Hughes C, Sander M, Hansen K, Christman K. (2018). Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogel. Tissue Engineering, 24, 697-708.
Nguyen-Ngoc K-V, Shamir ER, Huebner RJ, Beck JN, Cheung KJ, and Ewald AJ (2015). 3D culture assays of murine mammary branching morphogenesis and epithelial invasion. Methods Mol Bio. 1189: 135-162.
Nguyen-Ngoc K-V and Ewald AJ (2013). Mammary ductal elongation and myoepithelial migration are regulated by the composition of the extracellular matrix. J Microsc. 251(3): 212-23.
Nguyen-Ngoc K-V, Cheung KJ, Brenot A, Shamir ER, Gray RS, Hines WC, Yaswen P, Werb Z, and Ewald AJ (2012). The ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. PNAS. 109, E2595-2604.
Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen K-V., Brugge JS, and Montell DJ. (2011). Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 25(7): 730-41.