Fenfen Liu, M.S.

Laboratory Manager

I obtained my M.S. degree in Biotechnology at the University of Massachusetts. In addition to keeping the Sander lab running, I perform mouse islet isolations and help with all aspects of metabolic studies in mice.

Publications:

Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR III, Metallo CM, Sander M. (2018) Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function. Cell Reports, 25, 2904–2918. 

Zeng C*, Mulas F*, Sui Y, Guan T, Tan Y, Liu F, Carrano AC, Huising MO, Yeo GW, and Sander M. (2017) Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation. Cell Metabolism 25: 1-16. *equal contributors

Pissios P, Hong S, Kennedy AR, Prasad D, Liu FF, Maratos-Flier E. (2013) Methionine and choline regulate the metabolic phenotype of a ketogenic diet. Mol Metab. 2(3): 306-13.

Taylor BL, Liu FF, and Sander M. (2013) Nkx6.1 is Essential for Maintaining the Functional State of Pancreatic Beta Cells. Cell Reports 4(6):1262-75.

Kopp JL, Figura GV, Mayes E, Liu FF, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CVE, Jensen K, Hebrok M, and Sander M. (2012) Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma. Cancer Cell 22: 1–14.

Bradley RL, Jeon JY, Liu FF, and Maratos-Flier E. (2008) Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice. Am J Physiol Endocrinol Metab. 295(3): E586-94.

Pissios P, Frank L, Kennedy AR, Porter DR, Marino FE, Liu FF, Pothos EN, and Maratos-Flier E. (2008) Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice. Biol Psychiatry 64(3): 184-91.

Yan X, Schuldt AJ, Price RL, Amende I, Liu FF, Okoshi K, Ho KK, Pope AJ, Borg TK, Lorell BH, and Morgan JP. (2008) Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes. Am J Physiol Heart Circ Physiol. 294(3): H1274-81.

Handschin C, Chin S, Li P, Liu FF, Maratos-Flier E, Lebrasseur NK, Yan Z, and Spiegelman BM. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.J Biol Chem. 282(41): 30014-21.

Liu FF, Stone JR, Schuldt AJ, Okoshi K, Okoshi MP, Nakayama M, Ho KK, Manning WJ, Marchionni MA, Lorell BH, Morgan JP, and Yan X. (2005) Heterozygous knockout of neuregulin-1 gene in mice exacerbates doxorubicin-induced heart failure. Am J Physiol Heart Circ Physiol. 289(2): H660-6.