Wen Jin, Ph.D.

JDRF Research Fellow

I completed my Ph.D. in Dr. Rama Natarajan’s lab at City of Hope, Irell & Manella Graduate School of Biological Sciences. My graduate work led to the identification of several novel genes and non-coding RNAs regulated by Angiotensin II. Further characterization of some of these Angiotensin II targets has confirmed different roles for them in vascular smooth muscle cell dysfunction. In the Sander lab, my focus is on characterizing the role of small non-coding RNAs during pancreas development.

 

Publications:

Zeng C*, Mulas F*, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, and Sander M. (2017) Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation. Cell Metabolism 25: 1160-1175. *equal contributors

Reddy MA, Das S, Zhuo C, Jin W, Wang M, Lanting L, and Natarajan R. (2016) Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504. Arterioscler Thromb Vasc Biol. 36(5): 864-73.

Yuan H, Reddy MA, Deshpande S, Jia Y, Park JT, Lanting LL, Jin W, Kato M, Xu ZG, Das S, and Natarajan R. (2016) Epigenetic Histone Modifications Involved in Profibrotic Gene Regulation by 12/15-Lipoxygenase and Its Oxidized Lipid Products in Diabetic Nephropathy. Antioxid Redox Signal. 24(7): 361-75.

Leung A, Trac C, Jin W, Lanting L, Akbany A, Sætrom P, Schones DE, and Natarajan R. (2013) Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells. Circ Res. 113(3): 266-78.

Jin W, Reddy MA, Chen Z, Putta S, Lanting L, Kato M, Park JT, Chandra M, Wang C, Tangirala RK, and Natarajan R (2012). Small RNA sequencing reveals microRNAs that modulate angiotensin II effects in vascular smooth muscle cells. J Biol Chem. 287(19): 15672-83.

Reddy MA, Jin W, Villeneuve L, Wang M, Lanting L, Todorov I, Kato M, and Natarajan R. (2012) Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice. Arterioscler Thromb Vasc Biol. 32(3): 721-9.

Meng Z, Wang Y, Wang L, Jin W, Liu N, Pan H, Liu L, Wagman L, Forman BM, and Huang W. (2010) FXR regulates liver repair after CCl4-induced toxic injury. Mol Endocrinol. 24(5): 886-97.