Chun Zeng, Ph.D.
Assistant Project Scientist
I first became interested in diabetes research while in graduate school in Dr. Yong Zhao’s lab at the Chinese Academy of Sciences where I studied the contribution of T cells in the pathogenesis of type 1 and type 2 diabetes. After graduation, I joined Dr. Anil Bhushan’s lab at UCLA as a postdoctoral fellow to gain expertise in the area of beta cell biology. As a postdoctoral fellow in the Sander lab, my research aims to identify the cellular events that lead to cell cycle arrest in postnatal beta cells and develop approaches for expanding functional beta cell mass in patients with diabetes.
Xie Q, Wu T, Gimple R, Li Z, Prager B, Wu Q, Yu Y, Wang P, Wang Y, Gorkin D, Zhang C, Dowiak A, Lin K, Zeng C, Sui Y, Kim L, Miller T, Jiang L, Lee C, Huang Z, Fang X, Zhai K, Mack S, Sander M, Bao S, Kerstetter-Fogle A, Sloan A, Xiao A, Rich J. (2018) N6-methyladenine DNA modification in glioblastoma. Cell, 175,1-16.
Carrano AC*, Mulas F*, Zeng C, and Sander M. (2017) Interrogating Islets in Health and Disease with Single-Cell Technologies. Molecular Metabolism, 6(9):991-1001. *equal contributors
Zeng C*, Mulas F*, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, and Sander M. (2017) Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation. Cell Metabolism 25: 1160-1175. *equal contributors
Dhawan S, Tschen SI, Zeng C, Guo T, Hebrok M, Matveyenko A, and Bhushan A. (2015) DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest. 125(7): 2851-60.
Zhen Y, Sun L, Liu H, Duan K, Zeng C, Zhang L, Jin D, Peng J, Ding W, and Zhao Y. (2012) Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes. Cell Mol Immunol. 9(1): 75-85.
Zeng C, Shi X, Zhang B, Zhang L, Liu H, Ding W, and Zhao Y. (2012) The imbalance of Th17/Th1/Treg cells in patients with type 2 diabetes: Relationship with metabolic factors and complications. J Mol Med(Berl). 90(2): 175-86.
Javeed A, Zhang B, Qu Y, Zhang A, Sun C, Zhang L, Liu J, Zeng C, and Zhao Y. (2009) The significantly enhanced frequency of functional CD4(+)CD25(+)Foxp3(+) T regulatory cells in therapeutic dose aspirin-treated mice. Transpl Immunol. 20(4): 253-260.
Yi H, Zhen Y, Zeng C, Zhang L, and Zhao Y. (2008) Depleting anti-CD4 monoclonal antibody (GK1.5) treatment: influence on regulatory CD4+CD25+Foxp3+ T cells in mice. Transplantation 85(8): 1167-74.
Zhang A, Qu Y, Zhang B, Zhang L, Zeng C, Peng J, Ji Xn, Zhao Y, and Hou M. (2007) The different effects of indirubin on effector and CD4+CD25+ regulatory T cells in mice: potential implication for the treatment of autoimmune diseases. J Mol Med(Berl). 85(11): 1263-70.
Wu T, Zhen Y, Zeng C, Yi H, and Zhao Y. B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activation. Immunol Cell Biol. 2007, 85(8): 590-5.
Zeng C, Zhen Y, Shu S, Wu T Yi H, Lian Z, and Zhao Y. (2007) The influence of cyclosporin A on lymphocyte attenuator expression. J Autoimmun. 28(4): 234-44.
Qu Y, Zhang B, Zhang L, Liu G, Ma H, Rao E, Zeng C, and Zhao Y. (2007) The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice. Transpl Immunol. 17(3): 153-61.
Zeng C, Wu T, Zhen Y, Xia X, and Zhao Y. (2005) BTLA, a new inhibitory B7 family receptor with a TNFR family ligand. Cell Mol Immunol. 2(6): 427-32.