Andrea Carrano, Ph.D.

Grant Proposal and Manuscript Writer

I received my Ph.D. in Molecular Oncology and did my research training in the laboratory of Michele Pagano, M.D. in the Department of Pathology at the NYU Cancer Center. My research focused on cell signaling pathways involved in tumorigenesis. After receiving my degree, I joined Tony Hunter’s lab at the Salk Institute for Biological Studies to study nutrient signaling pathways driving aging. I then continued my research as a project scientist in Eric Bennett’s lab at UCSD to understand how the ubiquitin-modified proteome changes with aging. Through the course of my training and research, I gained expertise in writing/editing grant applications, abstracts, and manuscripts, which led me to pursue a career in science writing. Working as a writer in the Sander lab, I help researchers translate their innovative ideas into funded grants as well as help them communicate and publish their scientific findings.

 

Publications

Carrano AC *,Mulas F *, Zeng C, and Sander M. (2017) Interrogating islets in health and disease with single-sell technologies. Molecular Metabolism (in press). *equal contributors

Zeng C*, Mulas F*, Sui Y, Guan T, Miller N, Tan Y, Liu F, Jin W, Carrano AC, Huising MO, Shirihai OS, Yeo GW, and Sander M. (2017) Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta cell proliferation. Cell Metabolism 25: 1160-1175. *equal contributors

Benthuysen J, Carrano AC, and Sander M. (2016) Advances in cell replacement and regeneration strategies for treating diabetes. J Clin Invest. 126: 3651-3660.

Heimbucher T, Liu Z, Bossard C, McCloskey R, Carrano AC, Riedel CG, Tanasa B, Klammt C, Fonslow BR, Riera CE, Lillemeier BF, Kemphues K, Yates III JR, O’Shea C, Hunter T, and Dillin A. (2015) The deubiquitylase MATH-33 controls DAF-16 stability and function in metabolism and longevity. Cell Metab. 22: 151-163.

Xie R, Carrano AC, and Sander M. (2015) A systems view of the epigenetic networks regulating pancreas development and beta-cell function. Wiley Interdiscip Rev Syst Biol Med. 7: 1-11.

Carrano AC, Dillin A, and Hunter T. (2014) A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans. Nat Commun. 5: 3772.

Carrano AC and Bennett EJ. (2013) Using the ubiquitin-modified proteome to monitor protein homeostasis function. Mol Cell Proteomics12:3521-3531.

Carrano AC, Lui Z, Dillin A, and Hunter T. (2009) A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460: 396-399.

Carrano AC and Pagano M. (2001) Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression. J Cell Biol. 153: 1381-1390.

Hershko D, Bornstein G, Ben-Izhak O, Carrano AC, Pagano M, Krausz MM, and Hershko A. (2001) Inverse relationship between levels of p27kip1 and its ubiquitin ligase subunit Skp2 in colorectal cancers.Cancer 91: 1745-1751.

Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ERE, Finnin MS, Elledge SJ, Harper JW, Pagano M, and Pavletich NP. (2000) Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Nature 408: 381-386.

Carrano AC, Eytan E, Hershko A, and Pagano M. (1999) Skp2 is required for ubiquitin-mediated degradation of the Cdk inhibitor p27. Nat Cell Biol. 1: 193-199. Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, and Pagano M. (1999). Ubiquitination of p27 is regulated Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13, 1181-1189.

Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, and Ciechanover A. (1999). Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkBa. J Biol Chem. 274, 14823-14830.

Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, and Pagano M. (1999). Ubiquitination of p27 is regulated Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13, 1181-1189.

 

Invited Commentaries/Articles

Carrano AC. (2016) Granted: Writing and Packaging Winning Proposals. Postscripts 6: 193.

Carrano AC. (2015) EcSTAT3ic about K63-linked ubiquitylation of IKKβ. Cell Cycle 14: 1621-1622.

Carrano AC and Hunter T. (2015) Fitting WWP-1 in the dietary restriction network. Cell Cycle 14: 1485-1486.