Jenny (Jinzhao) Wang

hPSC Research Associate

I obtained my B.S degree in Biology from Lanzhou University, Lanzhou, China. In the Sander lab, I specialize in maintaining human pluripotent stem cell cultures and differentiating human pluripotent stem cells into pancreatic beta cells. I also play a key role in developing, operating, and adapting pancreatic beta cell differentiation protocols across multiple human stem cell lines.

 

Publications:

Vinckier N, Wang J, and Sander M. (2016) “Pancreatic Differentiation from Human Pluripotent Stem Cells.” Working with Stem Cells. Ed. Henning Ulrich, Ed. Priscilla Davidson Negraes. Switzerland: Springer International Publishing, 257-275.

Wang A, Yue F, Li Y, Xie R, Harper T, Patel NA, Muth K, Palmer J, Qiu Y, Wang J, Lam DK, Raum JC, Stoffers DA, Ren B, and Sander M. (2015) Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates. Cell Stem Cell 16(4): 386-99.

Joy MS, Roberts BV, Wang J, Hu Y, Hogan SL, and Falk RJ. (2014) A pilot study of leukocyte expression patterns for drug metabolizing enzyme and transporter transcripts in autoimmune glomerulonephritis. Int J Clin Pharmacol Ther. 52(4): 303-13.

Zhang X, Tao Y, Wang J, Garcia-Mata R, and Markovic-Plese S. (2013) Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis. Eur. J. Immunol. 43: 281–289.

Jiang W, Wang J, and Zhang Y. (2013) Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway. Cell Research. 23: 122-130.

Joy MS, La M, Wang J, Bridges AS, Hu Y, Hogan SL, Frye RF, Blaisdell J, Goldstein JA, Dooley MA, Brouwer KL, and Falk RJ. (2012) Cyclophosphamide and 4-hydroxycyclophosphamide pharmacokinetics in patients with glomerulonephritis secondary to lupus and small vessel vasculitis. Br J Clin Pharmacol. 74(3): 445-55.

Joy MS, Boyette T, Hu Y, Wang J, La M, Hogan SL, Stewart PW, Falk RJ, Dooley MA, and Smith PC. (2010) Effects of uridine diphosphate glucuronosyltransferase 2B7 and 1A7 pharmacogenomics and patient clinical parameters on steady-state mycophenolic acid pharmacokinetics in glomerulonephritis. Eur J Clin Pharmacol. 66(11): 1119-30.

Brooks C, Wang J, Yang T, and Dong Z. (2007) Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Am J Physiol Renal Physiol. 292(1): F243-52.

Wang J, Biju MP, Wang MH, Haase VH, and Dong Z. (2006) Cytoprotective effects of hypoxia against cisplatin-induced tubular cell apoptosis: involvement of mitochondrial inhibition and p53 suppression. J Am Soc Nephrol. 17(7): 1875-85.

Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, and Dong Z. (2006). ATM cleavage during cisplatin-induced tubular cell apoptosis. Am J Physiol Renal Physiol. 291: F1300–F130.

Jiang M, Wei Q, Wang J, Du Q, Yu J, Zhang L, and Dong Z. (2006). Regulation of PUMA-a by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25: 4056–4066.

Brooks C, Wang J, Yang T, Dong Z. (2006) Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Am J Physiol Renal Physiol. 292: F243–F252.

Yi X, Wang J, Seol DW, and Dong Z. (2006) Characterization of cell clones stably transfected with short form caspase-9:  apoptotic resistance and Bcl-XL expression. Mol Cell Biochem. 282(1-2): 12.

Brooks C, Ketsawatsomkron P, Sui Y, Wang J, Wang CY, Yu FS, and Dong Z. (2005) Acidic pH inhibits ATP depletion- induced tubular cell apoptosis by blocking caspase-9 activation in apoptosome. Am J Physiol Renal Physiol. 289: F410-F419.

Wang J, Wei Q, Wang CY, Hill WD, Hess DC, and Dong Z. (2004) Minocycline Up-regulates Bcl-2 and Protects against cell Death in Mitochondria. J Biol Chem. 279(19): 19948-54.

Dong Z and Wang J (2004) Hypoxia selection of death-resistant cells. J Biol Chem. 279(10): 9215-21.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, and Wang CY. (2004) A functional variant of SUMO4, a new IkBα modifier, is associated with Type 1.  Nature Genetics. 36: 837-41.

Zhang J, Li H, Wang J, Dong Z, Mian S, and Yu FSX. (2004) Role of EGFR transactivation in preventing apoptosis in Pseudomonas aeruginosa–infected human corneal epithelial cells. Invest Ophthalmol Vis Sci. 45: 2569- 2576.

Wei Q, Wang J, Wang MH, Yu F, and Dong Z. (2004) Inhibition of apoptosis by Zn2+ in renal tubular cells following ATP Depletion. Am J Physiol Renal Physiol. 287: F492-500.

Dong Z, Wang J, and Zong Q. (2003) Post-mitochondrial regulation of apoptosis by bicarbonate. Exp Cell Res. 288: 301-12.

Dong Z, Wang J, Yu F, and Venkatachalam MA. (2003) Apoptosis resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Journal of Pathology. 163: 663-671.

Dong Z, Venkatachalam MA, Wang J, Patel Y, Saikumar P, Semenza GL, Force T, and Nishiyama J. (2001) Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia. Hif-1-independent mechanisms. J Biol Chem. 276(22): 18702-9.